宋庆鑫 办公地址：南京农业大学理科楼 A626

电子邮箱：qxsong@njau.edu.cn

个人简介：

2006 年本科毕业于沈阳农业大学，2006-2013 年在中国科学院遗传与发育生物学研究 所攻读博士学位，期间主要研究种子油脂合成调控的分子机理。2013 年-2018 年，在 美国 The University of Texas at Austin 从事博士后研究，主要从表观遗传修饰和 转录调控网络两个角度研究杂种优势和多倍体化形成的遗传机制。2018 年 9 月作为南 京农业大学高层次引进人才到农学院任教授、博士生导师。迄今共发表SCI 论文20 篇， 累计影响因子 165。其中第一或并列第一作者论文 8 篇，分别发表在《PNAS》、《Genome Biology》、《Nature Communications》、《PLoS Genetics》、《Molecular Plant》等著名学术期刊上。论文被他人引用 1365 次，其中 4 篇论文入选ESI 高被引论文。

研究方向：

1 种子发育的分子机理： 种子发生过程中，各个组分尤其是胚和胚乳之间通过相互通信，精确调控发育状态。在 种子发育的不同时期包括胚珠受精前，不同组分之间呈现出不同的基因表达模式以及代 谢网络，如何优化这些组分的调控网络是改良作物种子产量和品质的关键。课题组将通 过正向遗传以及反向遗传相结合的方法，综合利用单细胞组学、生物信息学、表观遗传 学和生物化学等手段，解析种子从开花受精到成熟的过程中，各个组分之间的通信机制 以及发育调控的表观遗传机理。

2 种子进化的表观遗传调控 ？ 调控 胚 胚乳 种皮 种子发育过程 在自然进化和人工驯化过程中，种子性状发生巨大变化。我们之前的研究表明表观遗传 在作物进化和驯化过程中起到关键作用。课题组将通过表观遗传组关联分析（EWAS）和 表观遗传编辑等手段，研究表观遗传调控在作物种子进化和驯化中的作用以及鉴定与作 物种子产量和品质相关的表观遗传位点。

课题组热烈欢迎对表观遗传学、功能基因组学和生物信息学感兴趣的同学加入，希望帮 助学生在生物学的多个维度得到全方位的锻炼，鼓励学生提出并开展自己感兴趣的科研 项目，欢迎感兴趣的学生随时和我联系。

发表论文(#: co-first author)：

Song Q, Ando A, Xu D, Fang L, Zhang T, Huq E, Qiao H, Deng XW, Chen ZJ. (2018) Diurnal downregulation of ethylene biosynthesis mediates biomass heterosis. PNAS. 115: 5606-5611. Song Q, Zhang T, Stelly D and Chen ZJ. (2017) Epigenomic and functional analyses revealed roles of epialleles in the loss of photoperiod sensitivity during domestication of allotetraploid cottons. Genome Biology. 18:99.

Song Q, Guan X and Chen ZJ. (2015) Dynamic Roles for Small RNAs and DNA Methylation during Ovule and Fiber Development in Allotetraploid Cotton. PLoS Genetics 11:e1005724. Miller M# ,

Song Q# , Shi X, Juenger TE and Chen, ZJ. (2015) Natural variation in timing of stressresponsive gene expression predicts heterosis in intraspecific hybrids of Arabidopsis. Nature Communications 6:7453.

Song Q and Chen, ZJ. (2015) Epigenetic and developmental regulation in plant polyploids. Current Opinion Plant Biology 24:101-109.

Song QX# , Li QT# , Liu YF, Zhang FX, Ma B, Zhang WK, Man WQ, Du WG, Wang GD, Chen SY and Zhang JS. (2013) Soybean GmbZIP123 gene enhances lipid content in the seeds of transgenic Arabidopsis plants. Journal of Experimental Botany 64:4329-4341.

Song QX, Lu X, Li QT, Chen H, Hu XY, Ma B, Zhang WK, Chen SY and Zhang JS. (2013) Genomewide analysis of DNA methylation in soybean. Molecular Plant 6:1961-1974.

 进化和驯化

Song QX, Liu YF, Hu XY, Zhang WK, Ma B, Chen SY and Zhang JS. (2011) Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing. BMC Plant Biology 11:5.

Li QT, Lu X, Song QX, Chen HW, Wei W, Tao JJ, Bian XH, Shen M, Ma B, Zhang WK, Bi YD, Li W, Lai YC, Lam SM, Shui GH, Chen SY and Zhang JS. (2017) Selection for a Zinc-Finger Protein Contributes to Seed Oil Increase during Soybean Domestication. Plant Physiology 173:2208-2224.

Zheng D, Ye W, Song Q, Han F, Zhang T and Chen ZJ. (2016) Histone Modifications Define Expression Bias of Homoeologous Genomes in Allotetraploid Cotton. Plant Physiology 172:1760-1771.

Ko DK, Rohozinski D, Song Q, Taylor SH, Juenger TE, Harmon FG and Chen ZJ. (2016) Temporal Shift of Circadian-Mediated Gene Expression and Carbon Fixation Contributes to Biomass Heterosis in Maize Hybrids. PLoS Genetics 12:e1006197.

Zhang T, Hu Y, Jiang W, Fang L, Guan X, Chen J, Zhang J, Saski CA, Scheffler BE, Stelly DM, HulseKemp AM, Wan Q, Liu B, Liu C, Wang S, Pan M, Wang Y, Wang D, Ye W, Chang L, Zhang W, Song Q, Kirkbride RC, Chen X, Dennis E, Llewellyn DJ, Peterson DG0, Thaxton P, Jones DC, Wang Q, Xu X, Zhang H, Wu H, Zhou L, Mei G, Chen S, Tian Y, Xiang D, Li X, Ding J, Zuo Q, Tao L, Liu Y, Li J, Lin Y, Hui Y, Cao Z, Cai C, Zhu X, Jiang Z, Zhou B, Guo W, Li R and Chen ZJ. (2015) Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement. Nature Biotechnology 33:531-537.

Tuttle JR, Nah G, Duke MV, Alexander DC, Guan X, Song Q, Chen ZJ, Scheffler BE and Haigler CH. (2015) Metabolomic and transcriptomic insights into how cotton fiber transitions to secondary wall synthesis, represses lignification, and prolongs elongation. BMC Genomics 16:477.

Guan X, Song Q and Chen ZJ. (2014) Polyploidy and small RNA regulation of cotton fiber development. Trends Plant Science 19:516-528. Guan X, Nah G, Song Q, Udall JA, Stelly DM and Chen ZJ. (2014) Transcriptome analysis of extant cotton progenitors revealed tetraploidization and identified genome-specific single nucleotide polymorphism in diploid and allotetraploid cotton. BMC Research Notes 7:493.

Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG, Shui GH, Chen SY and Zhang JS. (2014) Soybean GmMYB73 promotes lipid accumulation in transgenic plants. BMC Plant Biolology 14:73.

Zou HF, Zhang YQ, Wei W, Chen HW, Song QX, Liu YF, Zhao MY, Wang F, Zhang BC, Lin Q, Zhang WK, Ma B, Zhou YH, Zhang JS and Chen SY. (2013) The transcription factor AtDOF4.2 regulates shoot branching and seed coat formation in Arabidopsis. Biochemical Journal 449:373-378.

Ma B, He SJ, Duan KX, Yin CC, Chen H, Yang C, Xiong Q, Song QX, Lu X, Chen HW, Zhang WK, Lu TG, Chen SY and Zhang JS. (2013) Identification of rice ethylene-response mutants and characterization of MHZ7/OsEIN2 in distinct ethylene response and yield trait regulation. Molecular Plant 6:1830-1848.

Hao YJ, Wei W, Song QX, Chen HW, Zhang YQ, Wang F, Zou HF, Lei G, Tian AG, Zhang WK, Ma B, Zhang JS and Chen SY. (2011) Soybean NAC transcription factors promote abiotic stress tolerance and lateral root formation in transgenic plants. Plant Journal 68:302-313.

Hao YJ, Song QX, Chen HW, Zou HF, Wei W, Kang XS, Ma B, Zhang WK, Zhang JS and Chen SY. (2010) Plant NAC-type transcription factor proteins contain a NARD domain for repression of transcriptional activation. Planta 232:1033-1043.