报告题目: A novel role for CHD remodelers in H3K27me3-dependent gene expression in plants
报 告 人: Joe Ogas, Associate Professor, Department of Biochemistry, Purdue University
时 间：2016年11月22日（周二）下午3:00起
地 点：国家重点实验室学术报告厅（理科楼A201）
报告人简介：
Dr. Joe Ogas received his Ph.D. training in the lab of Ira Herskowitz, University of California San Francisco, and conducted postdoctoral research in the lab of Chris Somerville, Stanford University. In 1998 he established his own lab in Department of Biochemistry, Purdue University. Dr. Ogas’ research focuses on studying the function and the molecular mechanism of CHD-family ATP-dependent chromatin remodeling factors in plants. CHD proteins are conserved in yeast, plants and animals and share similar functions in the regulation of transcription and developmental processes. He is interested in understanding how CHD proteins regulate developmental transitions through the chromatin remodeling activity and specific signaling pathways.
报告内容简介：
Plant development requires conditional gene expression that is facilitated by the coordinated action of epigenetic factors such as histone modifications, histone variants, and chromatin remodelers. The ATP-dependent chromatin remodeler PICKLE is known to promote the repressive epigenetic modification H3K27me3, which is associated with transcriptional repression of tissue-specific genes. Arabidopsis plants lacking PICKLE exhibit reduced levels of H3K27me3 in chromatin, both increased and decreased transcript levels of H3K27me3-enriched loci, and a variety of developmental defects. The mechanisms by which PICKLE promotes contributes to H3K27me3-associated events and plant development are unclear. We have undertaken a mutant screen that uncovered a genetic interaction between PICKLE and the SWR1-family chromatin remodeler PIE1, which promotes the histone variant H2A.Z in chromatin. Ongoing genome-wide analyses reveal unexpected connections between the chromatin remodeler PKL, the histone variant H2A.Z, and H3K27me3-associated processes.
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